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Understanding the basis of this selectivity makes it possible to guide enzyme design towards more efficient catalysts. Mutation screening was performed using denaturing gradient gel electrophoresis and DNA sequence analysis. All videos and links are provided by the parties. Furthermore, we describe TH as a best-in-class MTH1 inhibitor, which we expect to be useful in order to further validate the MTH1 inhibitor concept. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Ludwiginstitutet för cancerforskning.